22. Nick Kroll & John Mulaney

Nick Kroll and John Mulaney are a distinguished comedic duo known for their works, such as the cartoon sitcom Big Mouth and the film Oh, Hello on Broadway. To their credit, their on-stage chemistry is far from an act, and they are close friends in real life. They have been working together for more than a decade in the acting industry.

Nick and John have been working together, creating comedy, since 2005. With that said, they have known each other since their college days. They initially gained financial and critical acclaim working the Broadway play Oh, Hello – which would later have a Netflix adaptation, Oh, Hello on Broadway. In one of Nick’s interviews, he recalls the Broadway play to be the height of his career, having worked together with his best friend, John. Moreover, they even worked with John’s wife as the make-up artist of the production.